Anu RHEO+™ is a combination amniotic membrane matrix and Wharton’s Jelly that are minimally manipulated human tissue allografts, aseptically prepared for homologous use. Anu RHEO+™ aids in supplementing and replacing connective tissue that is damaged or inadequate. Amniotic ﬂuid is a rich source of nutrients, cytokines, and the growth factors necessary for fetal development and maturation, and naturally protects the baby from hard blows or harsh temperatures. Wharton’s Jelly is a rich source of MSCs helping with the development of the fetus through its growth stages. With this in mind, RHEO+™ is a perfect match for synovial fluid in joints and its properties that are anti-scarring, anti-adhesion and anti-inflammatory make it essential for healing tissue damage.
The amniotic membrane (AM) is a thin fetal membrane inside of the fetal placenta that is made up of the epithelium, basement membrane, and stroma. Extracted in a sterile environment during elective cesarean sections, they are screened for communicable diseases and treated with broad-spectrum antibiotics for future implementation.
AM can give rise to several different cell types through its pluripotent properties, making its anti-angiogenic and pro-apoptotic features valuable for procedures related to ocular surface reconstruction, skin application, and tissue engineering. The membrane’s application in tissue transplantation in particular is complimented by its anti-inflammatory, anti-bacterial, anti-viral and immunological characteristics.
Wharton’s jelly is a mucous tissue within the umbilical cord that protects and insulates blood cells made from mucopolysaccharides such as hyaluronic acid and chondroitin sulfate. With informed consent, Wharton’s jelly is obtained after normal vaginal delivery where they can be effectively isolated. They contain macrophages and fibroblasts, but among connective tissues, it is unique in containing mesenchymal regenerative cells (MSCs). The MSC within Wharton’s jelly consist of functional myofibroblasts that can be isolated with minimal manipulation of the tissue, easily preserving their natural anti-inflammatory and pro-regenerative ability without complication or deterioration.