Exosomes are extracellular vesicles released from cells upon the fusion of a multivesicular body within the plasma membrane, liberating intraluminal vesicles into an extracellular environment. While they are made as intraluminal vesicles, the multivesicular body they reside in regulates whether these vesicles would become exosomes. They are associated with cellular communication that transfers molecules through body fluids to deliver nutrients and transmit disease states. Their cell of origin determines the proteins, lipids, nucleic acids, DNA, and RNA species that act as passengers within an exosome. Exosomes regulate signaling, coagulation, and waste management as intercellular communicators and carry distinctive functions depending on how their molecule composition disperses.